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KMID : 0604520180440010015
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Journal of the Society of Cosmetic Scientists of Korea
2018 Volume.44 No. 1 p.15 ~ p.21
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Inductive Effects of the Cold Receptor TRPM8 Expression in Ganoderma lucidum Extracts and Ergosterol
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Ryu Hwa-Sun
Jeong Ji-Yeon
Jeon Weon-Ok
Lee Chun-Mong
Lee Jung-No
Park Sung-Min
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Abstract
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Skin-aging is accelerated by the increased expression of MMP-1 caused by the increased skin temperature induced by IR/visible light as well as UV. Thus, the control of skin temperature is important to inhibit heat-induced aging. Many studies have been conducted to lower the skin temperature through the controlling transient receptor potential melastatin 8 channel (TRPM8), which is known as the cold and menthol receptor 1 (CMR1) and is activated at temperature below 25 ℃. In this study, we first investigated the effect of Ganoderma lucidum extract (GLE) on the TRPM8 expression. Results showed that GLE, hexane (Hex) fractions and water fractions increased the TRPM8 expression in a dose dependent manner. Active compound in Hex fractions were separated by chromatography and analyzed by 1H and 13C NMR spectroscopy. The isolated compounds were identified as ergosterol and it also significantly increased the TRPM8 expression. Taken together, these results strongly suggest that G. lucidum extract and ergosterol have the potential as a new cooling ingredient in the cosmetics.
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KEYWORD
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Ganoderma lucidum extract, ergosterol, keratinocyte, cold and menthol receptor, TRPM8
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